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Tuesday, November 10, 2020 | History

3 edition of Analogues of nucleic acid components. found in the catalog.

Analogues of nucleic acid components.

P. Roy-Burman

Analogues of nucleic acid components.

Mechanisms of action

by P. Roy-Burman

  • 188 Want to read
  • 20 Currently reading

Published by Springer-Verlag in Berlin, New York .
Written in English

    Subjects:
  • Purines.,
  • Pyrimidines.,
  • Antibiotics.,
  • Antimetabolites.,
  • Antineoplastic agents.

  • Edition Notes

    Bibliography: p. 85-105.

    Statementby P. Roy-Burman.
    SeriesRecent results in cancer research,, 25
    Classifications
    LC ClassificationsRC261 .R35 no. 25
    The Physical Object
    Paginationx, 111 p.
    Number of Pages111
    ID Numbers
    Open LibraryOL5217338M
    LC Control Number75096737


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Analogues of nucleic acid components. by P. Roy-Burman Download PDF EPUB FB2

Sulfanilamide, a structural analogue of para­ aminobenzoic acid, interferes with the utilization of this metabolite in the synthesis of folic acid, an essential factor for growth. Bacteria synthesize their own folic acid and are incapable of utilizing exogenously available folic acid.

However, the situation is exactly opposite in the animal host. Detailed survey of sources, metabolic conversions, biological and clinical effects, and resistance-induction of purines, pyrimidines, and nucleoside antibiotics of interest in gout, cancer chemotherapy, and transplantation.

Analogues of Nucleic Acid Components. Mechanisms of Action. Roy-Burman. Edward Bresnick. Genre/Form: Fulltext Internet Resources: Additional Physical Format: Online version: Roy-Burman, P. Analogues of nucleic acid components. Berlin, New York, Springer. Additional Physical Format: Online-Ausg.

Analogues of Nucleic Acid Components Berlin, Heidelberg: Springer Berlin Heidelberg, Online-Ressource. Synthesis and Degradation of Nucleic Acid Components by Formamide and Cosmic Dust Analogues. Raffaele Saladino Prof.

E-mail address: [email protected] Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, Viterbo, Italy, Fax: (+39) ‐‐ Yasuo Komatsu, Eiko Ohtsuka, in RNA, Peptide nucleic acid. A nucleic acid analogue that contains a peptide backbone, called a “peptide nucleic acid” (PNA), was synthesized by Neilsen et al.

and was shown to bind to either single or double stranded DNA. The PNA DNA duplex had a much higher melting temperature than the DNA DNA duplex. 85 One reason for the extraordinarily. Nucleic acid components and their analogues.

CLX. Determination of the structure of the allaric portion of exotoxin from Bacillus thuringiensis by means of periodate oxidationVol. 38, Issue 8, pp. – R. Wightman and A. Holý Nucleic acid components and their analogues. CLIX. Nucleic Acids Book.

A free online book on the chemistry and biology of nucleic acids, written by Prof. Tom Brown and Dr Tom Brown (Jnr). The book is ideal for chemistry and biology students and also provides practical information for researchers working in the lab.

Andrea Michalkova, Jerzy Leszczynski, Towards Involvement of Interactions of Nucleic Acid Bases with Minerals in the Origin of Life: Quantum Chemical Approach, Practical Aspects of Computational Chemistry I, /, (), ().

Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research.

Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pentose sugar, either ribose or deoxyribose, and one of four analogue may have any of these altered. Nucleic Acid Components and Their Analogues: A Novel and Efficient Method for the Synthesis of a New Class of Bipyridyl and Biheterocyclic-Nitrogen Thioglycosides from Pyridine-2(1H)-thiones.

Peptide nucleic acid (PNA) Peptide nucleic acid (PNA) is a nucleic acid analogue in which the normal phosphate linkage found in DNA and RNA is replaced by an neutral peptide-like N-(2-aminoethyl)glycine backbone (Figure 1, Figure 2). Förster resonance energy transfer (FRET) using fluorescent base analogues is a powerful means of obtaining high-resolution nucleic acid structure and dynamics information that favorably complements techniques such as NMR and X-ray crystallography.

Here, we expand the base–base FRET repertoire with an adenine analogue FRET-pair. Phosphoramidite-protected quadracyclic 2′-deoxyadenosine. Chemical modification of nucleic acid components: conversion of guanosine by methyl N-cyanomethanimidate to a tricyclic, fluorescent analog of adenosine.

Nelson J. Leonard, Ramachandra S. Hosmane, Yankanagouda S. Agasimundin, Linda J. Kostuba, and ; Fred T. Oakes. adshelp[at] The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86A.

The use of fluorescent nucleic acid base analogues is becoming increasingly important in the fields of biology, biochemistry and biophysical chemistry as well as in the field of DNA nanotechnology.

The advantage of being able to incorporate a fluorescent probe molecule close to the site of examination in the nucleic acid-containing system of. To mitigate these problems, analogues of nucleic acids can be used.

These compounds are structurally similar to natural DNA, with alternative backbones. Due to their excellent affinity and specificity toward complementary strands, the most useful and popular nucleic acid analogues are peptide nucleic acid (PNA), locked nucleic acid (LNA) and.

Thus, stimulation of TLRs by nucleic acids is a promising area of research for the development of novel therapeutic strategies against pathogenic infection, allergies, malignant neoplasms and autoimmunity. This review summarizes the therapeutic applications of nucleic acids or nucleic acid analogues through the modulation of TLR signaling pathways.

An artificial nucleic acid analogue capable of self-assembly into a duplex merely through hydrophobic interactions is presented. The replacement of Watson–Crick hydrogen bonding with strictly hydrophobic interactions has the potential to confer new properties and facilitate the construction of.

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA.5/5(1).

Fluorescent Analogs of Biomolecular Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of.

Fusidic acid is only effective against gram-positive bacteria such as Streptococcus, Staphylococcus aureus and Corynebacterium minutissimum. Inhibitors of Nucleic Acid Synthesis and Function The selectivity of these agents is a result of differences in prokaryotic and eukaryotic enzymes affected by the antimicrobial agent.

As a first step towards this goal, various mono‐ and bifunctionalised (hetero‐ and homotopic) nucleic acid‐derived building blocks of type I–X have been synthesised for the generation of dynamic main‐chain and side‐chain reversible nucleic acid analogues. Hydrazide‐ and/or acetal (protected carbonyl)‐functionalised components.

Nucleic acids are the biopolymers, or large biomolecules, essential to all known forms of term nucleic acid is the overall name for DNA and RNA.

They are composed of nucleotides, which are the monomers made of three components: a 5-carbon sugar, a phosphate group and a nitrogenous the sugar is a compound ribose, the polymer is RNA (ribonucleic acid); if the sugar is derived.

Keywords:: Covid, RNA dependent-RNA polymerase, Pronucleotides, Peptide Nucleic Acid, In-silico Screening, Remdesivir analogues. Abstract:Introduction: The outburst of the novel coronavirus COVID, at the end of December has turned itself into a pandemic taking a heavy toll on human lives.

The causal agent being SARS-CoV-2, a member. The nucleoside analogue with a ribose lacking both 2' and 3' is called cordycepin, an anticancer drug. In the RNA world hypothesis there are several candidate original nucleic acids, such as PNA, TNA and GNA. A vast number of nucleobases analogues exist.

The most common application are used as fluorescent probes, either directly or indirectly. The topic of nucleic acids and components is discussed in detail in the middle up to the last part of the book, wherein electrical properties and energy transfer are explored.

Other aspects covered include developments in fluorescence; free radicals in aqueous solutions; and irradiated single crystals. Nucleoside analogues are nucleosides which contain a nucleic acid analogue and a sugar.

Nucleotide analogs are nucleotides which contain a nucleic acid analogue, a sugar, and a phosphate groups with one to three phosphates. Nucleoside and nucleotide analogues can be used in therapeutic drugs, include a range of antiviral products used to prevent viral replication in infected cells.

Nucleic acid analogues are compounds which are analogous (structurally similar) to naturally occurring RNA and DNA, used in medicine and in molecular biology research. Nucleic acids are chains of nucleotides, which are composed of three parts: a phosphate backbone, a pucker-shaped pentose sugar, either ribose or deoxyribose, and one of four analogue may have any of these altered.

Progress in the discovery of nucleic acid binding drugs naturally relies on the availability of analytical methods that assess the efficacy and nature of interactions between nucleic acids and their putative ligands. This progress can benefit tremendously from new methods that probe nucleic acid/ligand interactions both rapidly and quantitatively.

Previous work showed that the exocyclic amino groups of nucleic acid components react quickly at ambient temperature with acetaldehyde and ethanol to yield mixed acetals [R-NH-CH(CH3)-O-C2H5]. We now find that the same type of reaction occurs readily with the nitrogen of 3-substituted indoles (e.g., indoleacetic acid and N-acetyltryptophan.

Two of the four bases in nucleic acids, adenine and guanine, are purines. Purine analogues disrupt nucleic acid production. For example, azathioprine is the main immunosuppressive cytotoxic substance that is widely used in transplants to control rejection reactions by inhibiting DNA synthesis in lymphocytes.

Phadtare S, Zemlicka J. Allenic derivatives of nucleic acid components and their transformation products: a new class of biologically active nucleoside analogues. Nucleic Acids Symp Ser. ;(18)– Zhurkin VB, Poltev VI, Florent'ev VL. Atom-atomnye potentsial'nye funktsii dlia konformatsionnykh raschetov nukleinovykh kislot.

The sulfonamides (sulfa drugs) are the oldest synthetic antibacterial agents and are structural analogues of para-aminobenzoic acid (PABA), an early intermediate in folic acid synthesis (Figure ). By inhibiting the enzyme involved in the production of dihydrofolic acid, sulfonamides block bacterial biosynthesis of folic acid and.

Participants are cordially welcome to attend the 18 th Symposium on Chemistry of Nucleic Acid Components. It is a traditional (since ) conference covering synthetic, bioorganic and medicinal chemistry, biochemistry, biophysics, chemical biology and nanotechnology of nucleobases, nucleosides, nucleotides and nucleic acids.

Elemental analysis of the chimney precipitates and the reaction solutions showed that most of the metal cations that were determined were preferentially partitioned into the chimneys.

Key Words: RNA world—Hydrothermal systems—Prebiotic chemistry—Nucleic acids. Impact Factor. Nucleosides, Nucleotides & Nucleic Acids. Understanding the Chemistry of Nucleic Acid Components to Improve Human Health with oligonucleotide function. Finally, many nanotechnology tools depend on oligonucleotides and their chemical analogues to probe structure, function and mechanism.

The program will feature a keynote lecture and eight sessions that broadly address current. Primary Structure of Nucleic Acids. Nucleotides are joined together through the phosphate group of one nucleotide connecting in an ester linkage to the OH group on the third carbon atom of the sugar unit of a second nucleotide.

This unit joins to a third nucleotide, and the process is repeated to produce a long nucleic acid chain (Figure ). The titles may have gone unnecessarily too far in levels, for example: The color of those titles takes some neatness away from the pages.

The authors / publisher maintain a good website where corrections are made to the book. The book covers the chemistry of nucleic acids and its components impressively well in different chapters.Carbohydrates, proteins, lipids, and nucleic acids. 2.B. Describe at least one function of each group of organic compound.

Carbohydrates: main source of energy for plants and animals; proteins: regulation of cellular transportation of materials, cellular processes, formation of structures, and anti-bodies; lipids: storage of energy; storage or.

We have used this technique to evaluate the effects of 2′-O-methoxy ethyl (MOE) and constrained ethyl bicyclic nucleic acid (cEt) gapmer antisense oligonucleotides (ASOs). ASO tissue distribution was also characterized using immunohistochemical techniques, and MALAT1 mRNA reductions were confirmed by quantitative real time-polymerase chain.